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IF YOU HAVE NOT VOTED VIA THE IF YOU HAVE NOT VOTED (1) IF YOU HAVE NOT VOTED (2)U } I;} $ } } $ H     NxStage Medical, Inc.PRE 14A 04/14/2017Beneficial Ownership   Page 4 ,GENERAL INFORMATION ABOUT THE ANNUAL MEETING  ~    AND VOTING* "PROPOSAL 1 ? ELECTION OF DIRECTORS  ~  9 1PROPOSAL 2 ? ADVISORY VOTE ON OUR NAMED EXECUTIVE  ~  OFFICERS? COMPENSATION3+PROPOSAL 3 ? ADVISORY VOTE ON THE FREQUENCY~ "7/OF FUTURE ADVISORY VOTES ON OUR NAMED EXECUTIVEOFFICERS? COMPENSATION2*PROPOSAL 4 ? RATIFICATION OF THE SELECTION~ &7/OF OUR INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM0(PROPOSAL 5 ? AMENDMENT TO OUR BY-LAWS TO~ &5-ADOPT MAJORITY VOTING STANDARD IN UNCONTESTEDDIRECTOR ELECTIONS0(PROPOSAL 6 ? APPROVAL OF OUR AMENDED AND~ *0(RESTATED 2014 OMNIBUS INCENTIVE PLAN AND?162(m) MATERIAL TERMS-%STOCK OWNERSHIP OF CERTAIN BENEFICIAL~ bOWNERS AND MANAGEMENTCORPORATE GOVERNANCE~ j'Corporate Governance Guidelines~ j"Board Leadership Structure~ jDx l~rf*vW mO0 !"#$%&'()*+,-./0123456789:;<=>? Risk Oversight  ~ j +!#Board Determination of Independence!!~ !j!$"Communicating with Our Board""~ "n"##Director Nomination Process##~ #n#$Committees and Meetings$$~ $r$+%#Code of Business Conduct and Ethics%%~ %v%-&%Compensation Committee Interlocks and&&~ &v&'Insider Participation(Audit Committee Report((~ (v(-)%Fees of Independent Registered Public))~ )z)*Accounting Firm,+$Pre-Approval Policies and Procedures++~ +z+6,.CERTAIN RELATIONSHIPS AND RELATED TRANSACTIONS,,~ ,~,1-)Policies and Procedures Regarding Review,--~ -~-3.+Approval and Ratification of Related Person/ Transactions00(INFORMATION ABOUT EXECUTIVE AND DIRECTOR00~ 001 COMPENSATION,2$Compensation Discussion and Analysis22~ 22%3Compensation Committee Report33~ 33"4Summary Compensation Table44~ 44(5 2016 Grants of Plan-Based Awards55~ 5506(Outstanding Equity Awards at 2016 Fiscal66~ 667Year-End.8&2016 Option Exercises and Stock Vested88~ 88.9&Potential Payments Upon Termination or99~ 99:Change in Control;Director Compensation;;~ ;;0<(Securities Authorized for Issuance Under<<~ <<%=Our Equity Compensation Plans> OTHER MATTERS>>~ >>4?,Section 16(a) Beneficial Ownership Reporting??~ ??DW lSKf2_(0}Am@ABCDEFG@ Compliance-A%Delivery of Security Holder DocumentsAA~ AA1B)Stockholder Proposals for the 2018 AnnualBB~ BBCMeetingD$E____________________________1F)Created by Morningstar Document Research.0G(http://documentresearch.morningstar.com/0 =PF0*8X> @"GGFFEE  l  2  dMbP?_*+%,&٭e2?'٭e2?(٭e2?)٭e2?",D/??Beneficial OwnershipEquity Utilizat (1)Beneficial Owne (1)!STOCK OWNERSHIP OF CERTAIN BENESTOCK OWNERSHIP OF (1)Committees and MeetingsCommittees and (1)!Fees of Independent Registered !Compensation Discussion and Ana!How Executive Compensation is D Base SalaryAnnual Incentive PlanAnnual Incentive (1) IncentivesSummary CompensationStock Option GrantsOutstanding Equity Awards!2016 OPTION EXERCISES AND STOCK!Potential Payments Upon TerminaDirector Compensation2016 DIRECTOR COMPENSATION2016 DIRECTOR C (1)!Securities Authorized for Issua!AMENDED AND RESTATED 2014 OMNIB AMENDED AND RESTATED 2014 (1)! IF YOU HAVE NOT VOTED VIA THE IF YOU HAVE NOT VOTED (1) IF YOU HAVE NOT VOTED (2)U } } $ } m} $ } } $ }       NxStage Medical, Inc.PRE 14A 04/14/2017Equity Utilization Unvested Restricted   Stock Options  Unearned  Total Shares Under  Stock Units*    Performance Shares*  Outstanding Grants*~ ># ~  ~ b ~ G  $____________________________1)Created by Morningstar Document Research.0(http://documentresearch.morningstar.com/&Y@thd=PF0*8X> @ l  ;  dMbP?_*+%,&٭e2?'٭e2?(٭e2?)٭e2?",D/??Beneficial OwnershipEquity UtilizationBeneficial Owne (1)!STOCK OWNERSHIP OF CERTAIN BENESTOCK OWNERSHIP OF (1)Committees and MeetingsCommittees and (1)!Fees of Independent Registered !Compensation Discussion and Ana!How Executive Compensation is D Base SalaryAnnual Incentive PlanAnnual Incentive (1) IncentivesSummary CompensationStock Option GrantsOutstanding Equity Awards!2016 OPTION EXERCISES AND STOCK!Potential Payments Upon TerminaDirector Compensation2016 DIRECTOR COMPENSATION2016 DIRECTOR C (1)!Securities Authorized for Issua!AMENDED AND RESTATED 2014 OMNIB AMENDED AND RESTATED 2014 (1)! IF YOU HAVE NOT VOTED VIA THE IF YOU HAVE NOT VOTED (1) IF YOU HAVE NOT VOTED (2)U } } $ } } $ } } $ }       NxStage Medical, Inc.PRE 14A 04/14/2017Equity Utilization Year  Shares Granted*  Shares Forfeited  Gross Burn Rate*~  ~ Cz ~ h  3.1%~ ~ ~ a ~    2.5%~ z ~ rg ~   2.7% $____________________________1)Created by Morningstar Document Research.0(http://documentresearch.morningstar.com/(Tth/sg[3=PF0*8X> @ l  uD  dMbP?_*+%,&٭e2?'٭e2?(٭e2?)٭e2?",D/??Beneficial OwnershipEquity UtilizationEquity Utilizat (1)!STOCK OWNERSHIP OF CERTAIN BENESTOCK OWNERSHIP OF (1)Committees and MeetingsCommittees and (1)!Fees of Independent Registered !Compensation Discussion and Ana!How Executive Compensation is D Base SalaryAnnual Incentive PlanAnnual Incentive (1) IncentivesSummary CompensationStock Option GrantsOutstanding Equity Awards!2016 OPTION EXERCISES AND STOCK!Potential Payments Upon TerminaDirector Compensation2016 DIRECTOR COMPENSATION2016 DIRECTOR C (1)!Securities Authorized for Issua!AMENDED AND RESTATED 2014 OMNIB AMENDED AND RESTATED 2014 (1)! IF YOU HAVE NOT VOTED VIA THE IF YOU HAVE NOT VOTED (1) IF YOU HAVE NOT VOTED (2)U } 1} $} $ } U5      NxStage Medical, Inc.PRE 14A 04/14/2017Beneficial Ownership ?4,each person known by us to be the beneficial   2 *owner of more than 5% of our common stock;      $ ____________________________1)Created by Morningstar Document Research.0(http://documentresearch.morningstar.com/$j,~rf sg?=PF0*8X> @ l  .U[  dMbP?_*+%,&٭e2?'٭e2?(٭e2?)٭e2?",D/??Beneficial OwnershipEquity UtilizationEquity Utilizat (1)Beneficial Owne (1)STOCK OWNERSHIP OF (1)Committees and MeetingsCommittees and (1)!Fees of Independent Registered !Compensation Discussion and Ana!How Executive Compensation is D Base SalaryAnnual Incentive PlanAnnual Incentive (1) IncentivesSummary CompensationStock Option GrantsOutstanding Equity Awards!2016 OPTION EXERCISES AND STOCK!Potential Payments Upon TerminaDirector Compensation2016 DIRECTOR COMPENSATION2016 DIRECTOR C (1)!Securities Authorized for Issua!AMENDED AND RESTATED 2014 OMNIB AMENDED AND RESTATED 2014 (1)! IF YOU HAVE NOT VOTED VIA THE IF YOU HAVE NOT VOTED (1) IF YOU HAVE NOT VOTED (2)U } U5} $ } y} U} $ }  } $ .                                 NxStage Medical, Inc.PRE 14A 04/14/2017C;STOCK OWNERSHIP OF CERTAIN BENEFICIAL OWNERS AND MANAGEMENT Name  Shares    Percentage of    Beneficially Owned 1   Outstanding Shares 2 FMR LLC.  ~ J~    ffffff&@ % 245 Summer Street Boston, MA 02210&Gilder, Gagnon, Howe & Co. LLC~ ^~ !@ %%3 Columbus Circle, 26th FloorNew York, NY 10019 The Vanguard Group, Inc.~ f(~ @ %100 Vanguard Blvd.Malvern, PA 19355BlackRock, Inc.~ :~ ffffff@ %55 East 52nd StreetNew York, NY 10055Deerfield Mgmt, L.P.~ R~ @ %$780 Third Avenue, 37th FloorNew York, NY 10017Jeffrey H. Burbank~ ]ffffff@ %Joseph E. Turk, Jr.~ X *Reid S. Perper~   *Craig W. Moore~ >  * Earl R. Lewis~ :=  *Matthew W. Towse~   *Dx lcWK?hy\@dL$ ! " # $ % & ' ( ) * + , -  Winifred L. Swan  ~ N     * !Daniel A. Giannini!!~ !&!!! !*!"Robert G. Funari""~ """" "*"#Robert S. Brown##~ #0### #*#$ Jean K. Mixer$$~ $$$$ $*$%Barry M. Straube (8)%%~ %%%% %*%&James J. Peters&&~ &S&&& &*&'Heyward R. Donigan''~ ':>''' '*'4(,All current directors and executive officers((~ (C((((@ (%)as a group (13 persons)*$+____________________________1,)Created by Morningstar Document Research.0-(http://documentresearch.morningstar.com/ tdA5 =PF0*8X> @:--,,++     l  i  dMbP?_*+%,&٭e2?'٭e2?(٭e2?)٭e2?",D/??Beneficial OwnershipEquity UtilizationEquity Utilizat (1)Beneficial Owne (1)!STOCK OWNERSHIP OF CERTAIN BENECommittees and MeetingsCommittees and (1)!Fees of Independent Registered !Compensation Discussion and Ana!How Executive Compensation is D Base SalaryAnnual Incentive PlanAnnual Incentive (1) IncentivesSummary CompensationStock Option GrantsOutstanding Equity Awards!2016 OPTION EXERCISES AND STOCK!Potential Payments Upon TerminaDirector Compensation2016 DIRECTOR COMPENSATION2016 DIRECTOR C (1)!Securities Authorized for Issua!AMENDED AND RESTATED 2014 OMNIB AMENDED AND RESTATED 2014 (1)! IF YOU HAVE NOT VOTED VIA THE IF YOU HAVE NOT VOTED (1) IF YOU HAVE NOT VOTED (2)U } U5} $ }  } $      NxStage Medical, Inc.PRE 14A 04/14/2017C;STOCK OWNERSHIP OF CERTAIN BENEFICIAL OWNERS AND MANAGEMENT Name   Option Shares  Jeffrey H. Burbank  ~ .$  Joseph E. Turk, Jr.  ~ w   Reid S. Perper  ~ µ  Craig W. Moore  ~ µ  Earl R. Lewis~ rMatthew W. Towse~ YWinifred L. Swan~ %Daniel A. Giannini~ µRobert G. Funari~ %Robert S. Brown~ 25 Jean K. Mixer~ µBarry M. Straube~ James J. Peters~ SHeyward R. Donigan~ :>4,All current directors and executive officers~ bas a group (13 persons)$____________________________1)Created by Morningstar Document Research.0(http://documentresearch.morningstar.com/@ DcWK?r!>Rl=PF0*8X> @"  l  0Xzŀ  dMbP?_*+%,&٭e2?'٭e2?(٭e2?)٭e2?",D/??Beneficial OwnershipEquity UtilizationEquity Utilizat (1)Beneficial Owne (1)!STOCK OWNERSHIP OF CERTAIN BENESTOCK OWNERSHIP OF (1)Committees and (1)!Fees of Independent Registered !Compensation Discussion and Ana!How Executive Compensation is D Base SalaryAnnual Incentive PlanAnnual Incentive (1) IncentivesSummary CompensationStock Option GrantsOutstanding Equity Awards!2016 OPTION EXERCISES AND STOCK!Potential Payments Upon TerminaDirector Compensation2016 DIRECTOR COMPENSATION2016 DIRECTOR C (1)!Securities Authorized for Issua!AMENDED AND RESTATED 2014 OMNIB AMENDED AND RESTATED 2014 (1)! IF YOU HAVE NOT VOTED VIA THE IF YOU HAVE NOT VOTED (1) IF YOU HAVE NOT VOTED (2)U } <} $ } 8} $ } !} $ } } $ 0                                 NxStage Medical, Inc.PRE 14A 04/14/2017Committees and Meetings  Committee 0 (Principal Functions and Responsibilities  Members  Meetings        in 2016 Audit / '? Appoint, approve the compensation of, # Daniel A. Giannini (Chair)?  ~ &   5 -and assess the independence of our registered   Jean K. Mixer   public accounting firm.  Reid S. Perper3+? Oversee the work of our registered public.&accounting firm, including through the1)receipt and consideration of reports from the firm.0(? Review and discuss with management and-%our registered public accounting firm5-our annual and quarterly financial statements and related disclosures.6.? Monitor our internal controls over financial-%reporting and disclosure controls and procedures.3+? Provide oversight of information securityrisks..&? Oversee our internal audit function.-%? Establish policies regarding hiring7/employees from our registered public accounting/'firm and procedures for the receipt andD l{ocWGp!]w;q"A ! " # $ % & ' ( ) * + , - . /   2 *retention of accounting related complaints!!! and concerns.""."&? Meet independently with our internal##1#)audit staff, registered public accounting$$$firm and management.%%2%*? Review and approve or ratify any related&&&person transactions.' Compensation'5'-? Review and approve, or make recommendations''Craig W. Moore (Chair)''~ ''((6(.to our Board with respect to, the compensation((Heyward R. Donigan))")of our executive officers.))Robert G. Funari$*____________________________1+)Created by Morningstar Document Research.0,(http://documentresearch.morningstar.com/--)-!? Administer our incentive plans...0.(? Review and make recommendations to our//4/,Board with respect to director compensation.$%,7d,oe0=PF0*8X> @*,,++**   l    dMbP?_*+%,&٭e2?'٭e2?(٭e2?)٭e2?",D/??Beneficial OwnershipEquity UtilizationEquity Utilizat (1)Beneficial Owne (1)!STOCK OWNERSHIP OF CERTAIN BENESTOCK OWNERSHIP OF (1)Committees and Meetings!Fees of Independent Registered !Compensation Discussion and Ana!How Executive Compensation is D Base SalaryAnnual Incentive PlanAnnual Incentive (1) IncentivesSummary CompensationStock Option GrantsOutstanding Equity Awards!2016 OPTION EXERCISES AND STOCK!Potential Payments Upon TerminaDirector Compensation2016 DIRECTOR COMPENSATION2016 DIRECTOR C (1)!Securities Authorized for Issua!AMENDED AND RESTATED 2014 OMNIB AMENDED AND RESTATED 2014 (1)! 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Oversee an annual self-evaluation of our Board.4{oc{ ~xC|,=PF0*8X> @ l    dMbP?_*+%,&٭e2?'٭e2?(٭e2?)٭e2?",D/??Beneficial OwnershipEquity UtilizationEquity Utilizat (1)Beneficial Owne (1)!STOCK OWNERSHIP OF CERTAIN BENESTOCK OWNERSHIP OF (1)Committees and MeetingsCommittees and (1)!Compensation Discussion and Ana!How Executive Compensation is D Base SalaryAnnual Incentive PlanAnnual Incentive (1) IncentivesSummary CompensationStock Option GrantsOutstanding Equity Awards!2016 OPTION EXERCISES AND STOCK!Potential Payments Upon TerminaDirector Compensation2016 DIRECTOR COMPENSATION2016 DIRECTOR C (1)!Securities Authorized for Issua!AMENDED AND RESTATED 2014 OMNIB AMENDED AND RESTATED 2014 (1)! IF YOU HAVE NOT VOTED VIA THE IF YOU HAVE NOT VOTED (1) IF YOU HAVE NOT VOTED (2)U } } $ }  } $ }  } $                       NxStage Medical, Inc.PRE 14A 04/14/2017=5Fees of Independent Registered Public Accounting Firm  Fee Category ~   ~ ~   Audit Fees 1 ~ nms  ~ Gg  Audit-Related Fees 2  ~    ~ 2   Tax Fees 3  ~ Z*    ~   All Other Fees 4  ~ B   ~ B  Total Fees~ l~ |$____________________________1)Created by Morningstar Document Research.0(http://documentresearch.morningstar.com/.i]QEu'=PF0*8X> @J      l  N  dMbP?_*+%,&٭e2?'٭e2?(٭e2?)٭e2?",D/??Beneficial OwnershipEquity UtilizationEquity Utilizat (1)Beneficial Owne (1)!STOCK OWNERSHIP OF CERTAIN BENESTOCK OWNERSHIP OF (1)Committees and MeetingsCommittees and (1)!Fees of Independent Registered !How Executive Compensation is D Base SalaryAnnual Incentive PlanAnnual Incentive (1) IncentivesSummary CompensationStock Option GrantsOutstanding Equity Awards!2016 OPTION EXERCISES AND STOCK!Potential Payments Upon TerminaDirector Compensation2016 DIRECTOR COMPENSATION2016 DIRECTOR C (1)!Securities Authorized for Issua!AMENDED AND RESTATED 2014 OMNIB AMENDED AND RESTATED 2014 (1)! IF YOU HAVE NOT VOTED VIA THE IF YOU HAVE NOT VOTED (1) IF YOU HAVE NOT VOTED (2)U } } $ } I;      NxStage Medical, Inc.PRE 14A 04/14/2017,$Compensation Discussion and Analysis Jeffrey H. Burbank  Chief Executive Officer Joseph E. Turk, Jr.   President Matthew W. Towse 9 1Senior Vice President and Chief Financial Officer Robert S. Brown & President, NxStage Kidney Care Winifred L. Swan 1 )Senior Vice President and General Counsel$____________________________1)Created by Morningstar Document Research.0(http://documentresearch.morningstar.com/*hznbV2@zR=PF0*8X> @ l    dMbP?_*+%,&٭e2?'٭e2?(٭e2?)٭e2?",D/??Beneficial OwnershipEquity UtilizationEquity Utilizat (1)Beneficial Owne (1)!STOCK OWNERSHIP OF CERTAIN BENESTOCK OWNERSHIP OF (1)Committees and MeetingsCommittees and (1)!Fees of Independent Registered !Compensation Discussion and Ana Base SalaryAnnual Incentive PlanAnnual Incentive (1) IncentivesSummary CompensationStock Option GrantsOutstanding Equity Awards!2016 OPTION EXERCISES AND STOCK!Potential Payments Upon TerminaDirector Compensation2016 DIRECTOR COMPENSATION2016 DIRECTOR C (1)!Securities Authorized for Issua!AMENDED AND RESTATED 2014 OMNIB AMENDED AND RESTATED 2014 (1)! IF YOU HAVE NOT VOTED VIA THE IF YOU HAVE NOT VOTED (1) IF YOU HAVE NOT VOTED (2)U } y#} $ }       NxStage Medical, Inc.PRE 14A 04/14/20170(How Executive Compensation is Determined  Abaxis, Inc.   ABIOMED, Inc. Accuray Incorporated  Analogic Corporation AngioDynamics, Inc.  Atrion Corporation Cantel Medical Corp.  Cyberonics, Inc.  DexCom, Inc.  Endologix, Inc.%HeartWare International, Inc.ICU Medical, Inc.Insulet CorporationMasimo Corporation#Merit Medical Systems, Inc."Natus Medical IncorporatedNuVasive, Inc.!Spectranetics CorporationThoratec Corporation"Wright Medical Group, Inc.$____________________________1)Created by Morningstar Document Research.0(http://documentresearch.morningstar.com/4Evj^R.\:D8,=PF0*8X> @ l    dMbP?_*+%,&٭e2?'٭e2?(٭e2?)٭e2?",D/??Beneficial OwnershipEquity UtilizationEquity Utilizat (1)Beneficial Owne (1)!STOCK OWNERSHIP OF CERTAIN BENESTOCK OWNERSHIP OF (1)Committees and MeetingsCommittees and (1)!Fees of Independent Registered !Compensation Discussion and Ana!How Executive Compensation is DAnnual Incentive PlanAnnual Incentive (1) IncentivesSummary CompensationStock Option GrantsOutstanding Equity Awards!2016 OPTION EXERCISES AND STOCK!Potential Payments Upon TerminaDirector Compensation2016 DIRECTOR COMPENSATION2016 DIRECTOR C (1)!Securities Authorized for Issua!AMENDED AND RESTATED 2014 OMNIB AMENDED AND RESTATED 2014 (1)! 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Swan~ ~ " %$____________________________1)Created by Morningstar Document Research.0(http://documentresearch.morningstar.com/,8|{o=PF0*8X> @*   l    dMbP?_*+%,&٭e2?'٭e2?(٭e2?)٭e2?",D/??Beneficial OwnershipEquity UtilizationEquity Utilizat (1)Beneficial Owne (1)!STOCK OWNERSHIP OF CERTAIN BENESTOCK OWNERSHIP OF (1)Committees and MeetingsCommittees and (1)!Fees of Independent Registered !Compensation Discussion and Ana!How Executive Compensation is D Base SalaryAnnual Incentive (1) IncentivesSummary CompensationStock Option GrantsOutstanding Equity Awards!2016 OPTION EXERCISES AND STOCK!Potential Payments Upon TerminaDirector Compensation2016 DIRECTOR COMPENSATION2016 DIRECTOR C (1)!Securities Authorized for Issua!AMENDED AND RESTATED 2014 OMNIB AMENDED AND RESTATED 2014 (1)! 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Swan~ f %~  %  ~    % ~ . %$____________________________1)Created by Morningstar Document Research.0(http://documentresearch.morningstar.com/,|}qe8PD8=PF0*8X> @:    l    dMbP?_*+%,&٭e2?'٭e2?(٭e2?)٭e2?",D/??Beneficial OwnershipEquity UtilizationEquity Utilizat (1)Beneficial Owne (1)!STOCK OWNERSHIP OF CERTAIN BENESTOCK OWNERSHIP OF (1)Committees and MeetingsCommittees and (1)!Fees of Independent Registered !Compensation Discussion and Ana!How Executive Compensation is D Base SalaryAnnual Incentive Plan IncentivesSummary CompensationStock Option GrantsOutstanding Equity Awards!2016 OPTION EXERCISES AND STOCK!Potential Payments Upon TerminaDirector Compensation2016 DIRECTOR COMPENSATION2016 DIRECTOR C (1)!Securities Authorized for Issua!AMENDED AND RESTATED 2014 OMNIB AMENDED AND RESTATED 2014 (1)! IF YOU HAVE NOT VOTED VIA THE IF YOU HAVE NOT VOTED (1) IF YOU HAVE NOT VOTED (2)U } } $ }  } $      NxStage Medical, Inc.PRE 14A 04/14/2017Annual Incentive Plan   2016 Award ($)  Jeffrey H. Burbank  ~   Joseph E. Turk, Jr.  ~ ~   Matthew W. Towse  ~ Ґ  Robert S. Brown  ~ H Winifred L. Swan~ BZ$____________________________1)Created by Morningstar Document Research.0(http://documentresearch.morningstar.com/,|}qe)JaUI!=PF0*8X> @"  l    dMbP?_*+%,&٭e2?'٭e2?(٭e2?)٭e2?",D/??Beneficial OwnershipEquity UtilizationEquity Utilizat (1)Beneficial Owne (1)!STOCK OWNERSHIP OF CERTAIN BENESTOCK OWNERSHIP OF (1)Committees and MeetingsCommittees and (1)!Fees of Independent Registered !Compensation Discussion and Ana!How Executive Compensation is D Base SalaryAnnual Incentive PlanAnnual Incentive (1)Summary CompensationStock Option GrantsOutstanding Equity Awards!2016 OPTION EXERCISES AND STOCK!Potential Payments Upon TerminaDirector Compensation2016 DIRECTOR COMPENSATION2016 DIRECTOR C (1)!Securities Authorized for Issua!AMENDED AND RESTATED 2014 OMNIB AMENDED AND RESTATED 2014 (1)! IF YOU HAVE NOT VOTED VIA THE IF YOU HAVE NOT VOTED (1) IF YOU HAVE NOT VOTED (2)U } 1} $} $ } 2      NxStage Medical, Inc.PRE 14A 04/14/2017 Incentives ?2*long-term equity compensation and targeted   0 (total compensation of executives holding   + #similar position in our peer group;  $ ____________________________1)Created by Morningstar Document Research.0(http://documentresearch.morningstar.com/$,|pj^R*=PF0*8X> @ l  !y   dMbP?_*+%,&٭e2?'٭e2?(٭e2?)٭e2?",D/??Beneficial OwnershipEquity UtilizationEquity Utilizat (1)Beneficial Owne (1)!STOCK OWNERSHIP OF CERTAIN BENESTOCK OWNERSHIP OF (1)Committees and MeetingsCommittees and (1)!Fees of Independent Registered !Compensation Discussion and Ana!How Executive Compensation is D Base SalaryAnnual Incentive PlanAnnual Incentive (1) IncentivesStock Option GrantsOutstanding Equity Awards!2016 OPTION EXERCISES AND STOCK!Potential Payments Upon TerminaDirector Compensation2016 DIRECTOR COMPENSATION2016 DIRECTOR C (1)!Securities Authorized for Issua!AMENDED AND RESTATED 2014 OMNIB AMENDED AND RESTATED 2014 (1)! IF YOU HAVE NOT VOTED VIA THE IF YOU HAVE NOT VOTED (1) IF YOU HAVE NOT VOTED (2)U } $} $ }  } $ }  }  $ }  } $ } y} $ }  } $ }  } $ } y} $ !     NxStage Medical, Inc.PRE 14A 04/14/2017Summary Compensation     # Name and Principal Position  Year   Salary   Stock   Option    Non-Equity    All Other    Total ($)       ~    Awards   Awards   Incentive Plan    Compensation           ($) 1   ($) 2    Compensation   ($) 4                   ($) 3 Jeffrey H. Burbank  ~     ~ A%   ~    ~ z[   ~    ~    ~ 0 Chief Executive Officer~  ~~ "  ~    ~ PL~ &%~ ~ ~  z~ BT  ~    ~ &L:~ "x~ >~ Joseph E. Turk, Jr~  ~   ~    ~ =~ ~ ~ ~ zn President~  ~~ n  ~  2   ~ v(&~ V~ ~ S~  z~ N  ~  :  ~ F~ J ~ ~ B;Matthew W. Towse~  ~ O  ~    ~ v~ Ґ~ ~ CChief Financial Officer~  ~~ r  ~  J  ~ k~ : ~ ~ R=~  z~ f  ~  :  ~ F~ n|~ ~ ~6Robert S. Brown~  ~   ~  fV  ~ i~ H~ ~ 46&President, NxStage Kidney Care~  ~~ #  ~  J  ~ k~ ~ ~ b9~  z~   ~  :  ~ F~ b~ ~ 3Winifred L. Swan~  ~   ~  fV  ~ i~ BZ~ ~ \;General Counsel~  ~~ B8  ~  N  ~ ~ s ~ ~ 6~  z~ M  ~  jP  ~ y~ G~ ~ B1$____________________________1)Created by Morningstar Document Research.D,l~rf :O`|&3 0 (http://documentresearch.morningstar.com/H=PF0*8X> @                l  %!9v:  dMbP?_*+%,&٭e2?'٭e2?(٭e2?)٭e2?",D/??Beneficial OwnershipEquity UtilizationEquity Utilizat (1)Beneficial Owne (1)!STOCK OWNERSHIP OF CERTAIN BENESTOCK OWNERSHIP OF (1)Committees and MeetingsCommittees and (1)!Fees of Independent Registered !Compensation Discussion and Ana!How Executive Compensation is D Base SalaryAnnual Incentive PlanAnnual Incentive (1) IncentivesSummary CompensationOutstanding Equity Awards!2016 OPTION EXERCISES AND STOCK!Potential Payments Upon TerminaDirector Compensation2016 DIRECTOR COMPENSATION2016 DIRECTOR C (1)!Securities Authorized for Issua!AMENDED AND RESTATED 2014 OMNIB AMENDED AND RESTATED 2014 (1)! IF YOU HAVE NOT VOTED VIA THE IF YOU HAVE NOT VOTED (1) IF YOU HAVE NOT VOTED (2)U } } $ } y } $ } y }  $ }  } $ }  } $ } y} $ }  } $ }  } $ }  } "$ } ## } $&$ } '' } (*$ } ++ } ,-$ %.......... . . . . ...................NxStage Medical, Inc.PRE 14A 04/14/2017Stock Option Grants      !"#$%&'()*+,   Grant    Committee    Estimated    Estimated  ! " All other $ % & Exercise or ( ) * Grant date ,   Date   Approval   future payouts   future payouts  ! "option $ % & base price ( ) * fair value       Date   under non-equity    under equity  ! "awards: $ % & of option ( ) * of stock and           incentive plan   incentive plan  ! " Number of $ % &awards ( ) *option           awards   awards  ! " securities $ % &($/Sh) ( ) *awards   ($) 1 (#) 2 !" underlying$%&'() *($) 4      !"options Name   Threshold  TargetMaximum ThresholdTargetMaximum ! "(#) 3$%&'()Jeffrey H. Burbank  ~  2  ~ -~ "D !"#$%&'()*+,-3/9/20163/7/2016     ~ N~ ~  !"#$%&'()*~ +,3/9/20163/7/2016      !"~ #]$%&')\(/@()*~ +z[,Joseph E. Turk, Jr.  ~  '   ~ O~ Bw !"#$%&'()*+,3/9/20163/7/2016     ~ 6~ V~ V !"#$%&'()*~ +,3/9/20163/7/2016      !"~ #R $%&')\(/@()*~ +=,Matthew W. Towse  ~  j  ~ r ~ *@ !"#$%&'()*+,3/9/20163/7/2016     ~ N~ .~  !"#$%&'()*~ +,3/9/20163/7/2016      !"~ #t$%&')\(/@()*~ +v,Robert S. Brown  ~  C  ~ R ~  !"#$%&'()*+,3/9/20163/7/2016     ~ ~>~ &h~  !"#$%&'()*~ +fV,3/9/20163/7/2016      !"~ #V]$%&')\(/@()*~ +i,Winifred L. Swan  ~  C  ~ R ~  !"#$%&'()*+,3/9/20163/7/2016     ~ ~>~ &h~  !"#$%&'()*~ +fV,3/9/20163/7/2016      !"~ #V]$%&')\(/@()*~ +i,DQ1lsgK>$K l8f5י .!.".#.$. !$"____________________________1#)Created by Morningstar Document Research.0$(http://documentresearch.morningstar.com/ P=PF0*8X> @j-$$,##,"", "#"# "#*+   "# &' *+   "# &' *+    "# &' *+     "# &' *+     "# &' *+ l  :c  dMbP?_*+%,&٭e2?'٭e2?(٭e2?)٭e2?",D/??Beneficial OwnershipEquity UtilizationEquity Utilizat (1)Beneficial Owne (1)!STOCK OWNERSHIP OF CERTAIN BENESTOCK OWNERSHIP OF (1)Committees and MeetingsCommittees and (1)!Fees of Independent Registered !Compensation Discussion and Ana!How Executive Compensation is D Base SalaryAnnual Incentive PlanAnnual Incentive (1) IncentivesSummary CompensationStock Option Grants!2016 OPTION EXERCISES AND STOCK!Potential Payments Upon TerminaDirector Compensation2016 DIRECTOR COMPENSATION2016 DIRECTOR C (1)!Securities Authorized for Issua!AMENDED AND RESTATED 2014 OMNIB AMENDED AND RESTATED 2014 (1)! IF YOU HAVE NOT VOTED VIA THE IF YOU HAVE NOT VOTED (1) IF YOU HAVE NOT VOTED (2)U } } $ }  } $ }  }  $ } } U} $ }  } $ }  } $ }  } U} $ }  } $ :     NxStage Medical, Inc.PRE 14A 04/14/2017!Outstanding Equity Awards            Option Awards    Stock Awards  Name  Grant    Number of    Number of   Option   Option    Number of    Market value    Date    securities    securities   exercise    expiration   shares or units    of shares or        underlying    underlying   price   date    of stock that   units of stock        unexercised    unexercised  ~        have not    that have notoptions   options (#)   vested (#) vested 1 ($) (#)   Unexercisable ExercisableJeffrey H. Burbank3/3/2010~      Q#@3/2/2017 5/27/2011~ "     ףp= 2@ 5/26/20183/9/2012~      {Gz2@3/8/20193/4/2013~ 2   ~  ~   (\&@3/3/2023 3/10/2014~ Z  ~  W~   RQ-@3/9/20243/3/2015~ y  ~  N ~   )\0@3/2/20253/3/2015     ~ ڵ~ ~ ,3/9/2016~   ~  bL ~   )\(/@3/8/2026Joseph E. Turk, Jr.3/3/2010~ N     Q#@3/2/2017 5/27/2011~      ףp= 2@ 5/26/20183/9/2012~ B     {Gz2@3/8/20193/4/2013~ f  ~  b@~   (\&@3/3/2023 3/10/2014~ Ύ  ~  )~   RQ-@3/9/20243/3/2015~ ޼  ~  *~   )\0@3/2/20253/3/2015     ~ N~ ~ DA"lymat0n%>BVe! !"#$%&'()*+,-./0123456789    3/9/2016   ~     ~ ~    )\(/@    3/8/2026         !Matthew W. Towse!!! 7/15/2013!!!~ !&!! ! ~ ! ~ ! ! !!,@!!!! 7/14/2023!!!!!!!!!"""" 7/15/2013"""""" " " " " """""""""~ ",~ """~ ""#### 3/10/2014###~ #Ύ## # ~ # )~ # # ##RQ-@####3/9/2024#########$$$$3/3/2015$$$~ $$$ $ ~ $ @~ $ $ $$)\0@$$$$3/2/2025$$$$$$$$$%%%%3/3/2015%%%%%% % % % % %%%%%%%%%~ %N~ %%%~ %%&&&&3/9/2016&&&~ &&& & ~ & n~ & & &&)\(/@&&&&3/8/2026&&&&&&&&&'Robert S. Brown''' 5/27/2011'''~ ''' ' ' ' ' ''ףp= 2@'''' 5/26/2018'''''''''((((3/9/2012(((~ ((( ( ( ( ( (({Gz2@((((3/8/2019((((((((())))3/4/2013)))~ )F)) ) ~ ) b@~ ) ) ))(\&@))))3/3/2023)))))))))**** 3/10/2014***~ *Ύ** * ~ * )~ * * **RQ-@****3/9/2024*********++++3/3/2015+++~ +++ + ~ + @~ + + ++)\0@++++3/2/2025+++++++++,,,,3/3/2015,,,,,, , , , , ,,,,,,,,,~ ,N~ ,,,~ ,,----3/9/2016---~ -~-- - ~ - ڋ~ - - --)\(/@----3/8/2026---------.Winifred L. Swan... 5/27/2011...~ ... . . . . ..ףp= 2@.... 5/26/2018.........////3/9/2012///~ /// / / / / //{Gz2@////3/8/2019/////////00003/4/2013000~ 000 0 ~ 0 R4~ 0 0 00(\&@00003/3/20230000000001111 3/10/2014111~ 1 11 1 ~ 1 ~ 1 1 11RQ-@11113/9/202411111111122223/3/2015222~ 2rl22 2 ~ 2 ~ 2 2 22)\0@22223/2/202522222222233333/3/2015333333 3 3 3 3 333333333~ 3{~ 333~ 3 344443/9/2016444~ 4~44 4 ~ 4 ڋ~ 4 4 44)\(/@44443/8/202644444444456$7____________________________18)Created by Morningstar Document Research.09(http://documentresearch.morningstar.com/8z!8;O^| 7+=PF0*8X> @*%998877                          l  h  dMbP?_*+%,&٭e2?'٭e2?(٭e2?)٭e2?",D/??Beneficial OwnershipEquity UtilizationEquity Utilizat (1)Beneficial Owne (1)!STOCK OWNERSHIP OF CERTAIN BENESTOCK OWNERSHIP OF (1)Committees and MeetingsCommittees and (1)!Fees of Independent Registered !Compensation Discussion and Ana!How Executive Compensation is D Base SalaryAnnual Incentive PlanAnnual Incentive (1) IncentivesSummary CompensationStock Option GrantsOutstanding Equity Awards!Potential Payments Upon TerminaDirector Compensation2016 DIRECTOR COMPENSATION2016 DIRECTOR C (1)!Securities Authorized for Issua!AMENDED AND RESTATED 2014 OMNIB AMENDED AND RESTATED 2014 (1)! IF YOU HAVE NOT VOTED VIA THE IF YOU HAVE NOT VOTED (1) IF YOU HAVE NOT VOTED (2)U } } $ }  } $ }  }  $ } } U} $ }  } $      NxStage Medical, Inc.PRE 14A 04/14/2017.&2016 OPTION EXERCISES AND STOCK VESTED         Option Awards    Stock Awards  Name  Number of Shares   Value Realized   Number of Shares   Value Realized    Acquired on Exercise    on Exercise   Acquired on Vesting    on Vesting   (#)   ($) 1   (#)  ~  Jeffrey H. Burbank  ~ 8   ~    ~ ֵ~   ~ y Joseph E. Turk, Jr.~ f~ >4  ~  J~   ~ R5 Matthew W. Towse~ ~ n&  ~  V~   ~ n Robert S. Brown  ~  J~   ~ R5 Winifred L. Swan~ ~~ 2  ~  {~   ~ j{$____________________________1)Created by Morningstar Document Research.0(http://documentresearch.morningstar.com/2 xl`T?s>XL@=PF0*8X> @            l  4cݼ  dMbP?_*+%,&٭e2?'٭e2?(٭e2?)٭e2?",D/??Beneficial OwnershipEquity UtilizationEquity Utilizat (1)Beneficial Owne (1)!STOCK OWNERSHIP OF CERTAIN BENESTOCK OWNERSHIP OF (1)Committees and MeetingsCommittees and (1)!Fees of Independent Registered !Compensation Discussion and Ana!How Executive Compensation is D Base SalaryAnnual Incentive PlanAnnual Incentive (1) IncentivesSummary CompensationStock Option GrantsOutstanding Equity Awards!2016 OPTION EXERCISES AND STOCKDirector Compensation2016 DIRECTOR COMPENSATION2016 DIRECTOR C (1)!Securities Authorized for Issua!AMENDED AND RESTATED 2014 OMNIB AMENDED AND RESTATED 2014 (1)! IF YOU HAVE NOT VOTED VIA THE IF YOU HAVE NOT VOTED (1) IF YOU HAVE NOT VOTED (2)U } } $ } %} $ }  } $ } y} $ } y} $ 4     NxStage Medical, Inc.PRE 14A 04/14/2017@8Potential Payments Upon Termination or Change in Control      Name  Severance Benefit   Termination    Termination   Change in Control       Without Cause    Without Cause   Under 2014 Plan     or Resignation   Three Months Before  ~      for Good Reason   Change in Control;    ~     Termination Without CauseAt Any Time After aChange in Control;Resignation for Good reasonDuring the 12 MonthsFollowing a Change in Control~ Jeffrey H. BurbankSeverance Payments~ P$~  Bʟ    Healthcare Benefits 1~ Z/~  ^    'Market Value of Stock Vesting 2~ *~  /   ~  r~ Total~ b~  *   ~  r~ Joseph E. Turk, Jr.Severance Payments~ 5 ~  *    Healthcare Benefits 1~ ~   0    'Market Value of Stock Vesting 2~ .~     ~  ] Tax Gross Up~  BE    D lfZNBn 6Z !"#$%&'()*+,-./0123   Total  ~ ;   ~ zZ   ~ ] !!!!! "Matthew W. Towse""Severance Payments""~ "r """~ " R " " " " "###Healthcare Benefits 1##~ ####~ # /# # # # #$$'$Market Value of Stock Vesting 2$$~ $"h'$$$~ $ ʦm$ $ $ ~ $ N}=$%% %Total%%~ %r2%%%~ % V% % % ~ % N}=%&Robert S. Brown . .&&Severance Payments&&~ &R &&&~ & & & & & &'''Healthcare Benefits 1''~ ''''~ ' /' ' ' ' '(('(Market Value of Stock Vesting 2((~ (\#(((~ ( : \( ( ( ~ ( b[3()) )Total))~ ){.)))~ ) |) ) ) ~ ) b[3)***** +Winifred L. Swan .++Severance Payments++~ +R +++~ + n{'+ + + + +,,,Healthcare Benefits 1,,~ ,,,,~ , .{, , , , ,--'-Market Value of Stock Vesting 2--~ ----~ - BQ- - - ~ - B.-.. .Total..~ .(...~ . z. . . ~ . B../0$1____________________________12)Created by Morningstar Document Research.03(http://documentresearch.morningstar.com/,2 |A+^CHl=PF0*8X> @332211                   l    dMbP?_*+%,&٭e2?'٭e2?(٭e2?)٭e2?",D/??Beneficial OwnershipEquity UtilizationEquity Utilizat (1)Beneficial Owne (1)!STOCK OWNERSHIP OF CERTAIN BENESTOCK OWNERSHIP OF (1)Committees and MeetingsCommittees and (1)!Fees of Independent Registered !Compensation Discussion and Ana!How Executive Compensation is D Base SalaryAnnual Incentive PlanAnnual Incentive (1) IncentivesSummary CompensationStock Option GrantsOutstanding Equity Awards!2016 OPTION EXERCISES AND STOCK!Potential Payments Upon Termina2016 DIRECTOR COMPENSATION2016 DIRECTOR C (1)!Securities Authorized for Issua!AMENDED AND RESTATED 2014 OMNIB AMENDED AND RESTATED 2014 (1)! IF YOU HAVE NOT VOTED VIA THE IF YOU HAVE NOT VOTED (1) IF YOU HAVE NOT VOTED (2)U } } $ }  } $ } <} $ } } $ }  } $ } <} $ }                      NxStage Medical, Inc.PRE 14A 04/14/2017Director Compensation       Committee Chair  Committee Member*  Board Chair  Audit   Compensation  Nominating and  Audit   Compensation  Nominating and        Corporate       Corporate        Governance       Governance~ b[ ~ 8 ~ b ~ B ~ B ~ 2u ~ "N$____________________________1)Created by Morningstar Document Research.0(http://documentresearch.morningstar.com/*h}qem*th@=PF0*8X> @*     l    dMbP?_*+%,&٭e2?'٭e2?(٭e2?)٭e2?",D/??Beneficial OwnershipEquity UtilizationEquity Utilizat (1)Beneficial Owne (1)!STOCK OWNERSHIP OF CERTAIN BENESTOCK OWNERSHIP OF (1)Committees and MeetingsCommittees and (1)!Fees of Independent Registered !Compensation Discussion and Ana!How Executive Compensation is D Base SalaryAnnual Incentive PlanAnnual Incentive (1) IncentivesSummary CompensationStock Option GrantsOutstanding Equity Awards!2016 OPTION EXERCISES AND STOCK!Potential Payments Upon TerminaDirector Compensation2016 DIRECTOR C (1)!Securities Authorized for Issua!AMENDED AND RESTATED 2014 OMNIB AMENDED AND RESTATED 2014 (1)! IF YOU HAVE NOT VOTED VIA THE IF YOU HAVE NOT VOTED (1) IF YOU HAVE NOT VOTED (2)U } a} $ }  } $ }  }  $ }  } $                            NxStage Medical, Inc.PRE 14A 04/14/2017"2016 DIRECTOR COMPENSATION       Fees Earned or   Option    Total ($)     Paid In Cash   Awards  ~    ($) 1 Heyward R. Donigan  ~ R   ~ JK   ~    Robert G. Funari  ~    ~    ~ >4 Daniel A. Giannini~ ~   ~  VZ   Earl R. Lewis~ ~   ~     Jean K. Mixer~ Ny~   ~  )  Craig W. Moore~ H~   ~    Reid S. Perper~ [~   ~  F  James J. Peters~ e~   ~  ^<  Barry M. Straube 2~ P~   ~    $____________________________1)Created by Morningstar Document Research.0(http://documentresearch.morningstar.com/8h xl`/ l^I=1 =PF0*8X> @R          l  *  dMbP?_*+%,&٭e2?'٭e2?(٭e2?)٭e2?",D/??Beneficial OwnershipEquity UtilizationEquity Utilizat (1)Beneficial Owne (1)!STOCK OWNERSHIP OF CERTAIN BENESTOCK OWNERSHIP OF (1)Committees and MeetingsCommittees and (1)!Fees of Independent Registered !Compensation Discussion and Ana!How Executive Compensation is D Base SalaryAnnual Incentive PlanAnnual Incentive (1) IncentivesSummary CompensationStock Option GrantsOutstanding Equity Awards!2016 OPTION EXERCISES AND STOCK!Potential Payments Upon TerminaDirector Compensation2016 DIRECTOR COMPENSATION!Securities Authorized for Issua!AMENDED AND RESTATED 2014 OMNIB AMENDED AND RESTATED 2014 (1)! IF YOU HAVE NOT VOTED VIA THE IF YOU HAVE NOT VOTED (1) IF YOU HAVE NOT VOTED (2)U } a} $ }  } $      NxStage Medical, Inc.PRE 14A 04/14/2017"2016 DIRECTOR COMPENSATION Name  Shares     Subject to   Stock   Options Heyward R. Donigan  ~ z Robert G. Funari~ %Daniel A. Giannini~ µ Earl R. Lewis~ r Jean K. Mixer~ µCraig W. Moore~ bReid S. Perper~ bJames J. Peters~ Barry M. Straube~  $____________________________1)Created by Morningstar Document Research.0(http://documentresearch.morningstar.com/:xl`$hz/Lq=PF0*8X> @:     l  0  dMbP?_*+%,&٭e2?'٭e2?(٭e2?)٭e2?",D/??Beneficial OwnershipEquity UtilizationEquity Utilizat (1)Beneficial Owne (1)!STOCK OWNERSHIP OF CERTAIN BENESTOCK OWNERSHIP OF (1)Committees and MeetingsCommittees and (1)!Fees of Independent Registered !Compensation Discussion and Ana!How Executive Compensation is D Base SalaryAnnual Incentive PlanAnnual Incentive (1) IncentivesSummary CompensationStock Option GrantsOutstanding Equity Awards!2016 OPTION EXERCISES AND STOCK!Potential Payments Upon TerminaDirector Compensation2016 DIRECTOR COMPENSATION2016 DIRECTOR C (1)!AMENDED AND RESTATED 2014 OMNIB AMENDED AND RESTATED 2014 (1)! IF YOU HAVE NOT VOTED VIA THE IF YOU HAVE NOT VOTED (1) IF YOU HAVE NOT VOTED (2)U } -} $ } y}  $ } y} $                          NxStage Medical, Inc.PRE 14A 04/14/2017NFSecurities Authorized for Issuance Under Our Equity Compensation Plans      Plan Category   Number of    Weighted-    Number of     Securities to   Average    Securities    be Issued   Exercise    Remaining   Upon   Price of    Available for    Exercise of    Outstanding   Future OutstandingOptions,  IssuanceOptions,Warrants   Under EquityWarrants and Rights 2   Compensation and Rights 1  Plans 3-%Equity compensation plans approved by~ 6b! ףp= .@  ~  } security holders$____________________________1)Created by Morningstar Document Research.0(http://documentresearch.morningstar.com/4 XL@4ncT@=PF0*8X> @                 l    dMbP?_*+%,&٭e2?'٭e2?(٭e2?)٭e2?",D/??Beneficial OwnershipEquity UtilizationEquity Utilizat (1)Beneficial Owne (1)!STOCK OWNERSHIP OF CERTAIN BENESTOCK OWNERSHIP OF (1)Committees and MeetingsCommittees and (1)!Fees of Independent Registered !Compensation Discussion and Ana!How Executive Compensation is D Base SalaryAnnual Incentive PlanAnnual Incentive (1) IncentivesSummary CompensationStock Option GrantsOutstanding Equity Awards!2016 OPTION EXERCISES AND STOCK!Potential Payments Upon TerminaDirector Compensation2016 DIRECTOR COMPENSATION2016 DIRECTOR C (1)!Securities Authorized for Issua AMENDED AND RESTATED 2014 (1)! IF YOU HAVE NOT VOTED VIA THE IF YOU HAVE NOT VOTED (1) IF YOU HAVE NOT VOTED (2)U } } $ } 0.      NxStage Medical, Inc.PRE 14A 04/14/201780AMENDED AND RESTATED 2014 OMNIBUS INCENTIVE PLAN NxSTAGE MEDICAL, INC.   By:     Darren Scandone  . &Senior Vice President, Human Resources$____________________________1)Created by Morningstar Document Research.0(http://documentresearch.morningstar.com/*hnbVJ&I=1 =PF0*8X> @"  l  /   dMbP?_*+%,&٭e2?'٭e2?(٭e2?)٭e2?",D/??Beneficial OwnershipEquity UtilizationEquity Utilizat (1)Beneficial Owne (1)!STOCK OWNERSHIP OF CERTAIN BENESTOCK OWNERSHIP OF (1)Committees and MeetingsCommittees and (1)!Fees of Independent Registered !Compensation Discussion and Ana!How Executive Compensation is D Base SalaryAnnual Incentive PlanAnnual Incentive (1) IncentivesSummary CompensationStock Option GrantsOutstanding Equity Awards!2016 OPTION EXERCISES AND STOCK!Potential Payments Upon TerminaDirector Compensation2016 DIRECTOR COMPENSATION2016 DIRECTOR C (1)!Securities Authorized for Issua!AMENDED AND RESTATED 2014 OMNIB! IF YOU HAVE NOT VOTED VIA THE IF YOU HAVE NOT VOTED (1) IF YOU HAVE NOT VOTED (2)U } $ } $} $ } F /     NxStage Medical, Inc.PRE 14A 04/14/201780AMENDED AND RESTATED 2014 OMNIBUS INCENTIVE PLAN  & Electronic Voting Instructions . &You can vote by Internet or telephone!0(Available 24 hours a day, 7 days a week!5-Instead of mailing your proxy, you may choose4,one of the two voting methods outlined belowto vote your proxy./'VALIDATION DETAILS ARE LOCATED BELOW INTHE TITLE BAR.6.Proxies submitted by the Internet or telephone/'must be received by 11:59 p.m., EasternTime, on May 24, 2017.Vote by Internet ?B:Log on to the Internet and go to www.investorvote.com/NXTM ?0(Follow the steps outlined on the securedwebsite.DlnbVJZ!qe+Z !"#$%&'()*+,-.  !!!Vote by telephone"""""## #?#3#+Call toll free 1-800-652-VOTE (8683) within$$$$1$)the USA, US territories & Canada any time%%%%5%-on a touch tone telephone. There is NO CHARGE&&&&&to you for the call.'''''(( (?(/('Follow the instructions provided by the)))))recorded message.*+$,____________________________1-)Created by Morningstar Document Research.0.(http://documentresearch.morningstar.com/"wAQ=PF0*8X> @..--,,!!   l    dMbP?_*+%,&٭e2?'٭e2?(٭e2?)٭e2?",D/??Beneficial OwnershipEquity UtilizationEquity Utilizat (1)Beneficial Owne (1)!STOCK OWNERSHIP OF CERTAIN BENESTOCK OWNERSHIP OF (1)Committees and MeetingsCommittees and (1)!Fees of Independent Registered !Compensation Discussion and Ana!How Executive Compensation is D Base SalaryAnnual Incentive PlanAnnual Incentive (1) IncentivesSummary CompensationStock Option GrantsOutstanding Equity Awards!2016 OPTION EXERCISES AND STOCK!Potential Payments Upon TerminaDirector Compensation2016 DIRECTOR COMPENSATION2016 DIRECTOR C (1)!Securities Authorized for Issua!AMENDED AND RESTATED 2014 OMNIB AMENDED AND RESTATED 2014 (1) IF YOU HAVE NOT VOTED (1) IF YOU HAVE NOT VOTED (2)U } U} $ } y<} $ } $      NxStage Medical, Inc.PRE 14A 04/14/2017kc IF YOU HAVE NOT VOTED VIA THE INTERNET OR TELEPHONE, FOLD ALONG THE PERFORATION, DETACH AND RETUR  A 5 -Proposals ? The Board of Directors recommends    6 .a vote FOR all the nominees listed in Proposal  8 01, FOR Proposals 2, 4, 5 and 6, and 1 YEAR on    Proposal 3.     +7/In their discretion, the proxies are authorized80to vote upon such other business as may properly:2come before the Annual Meeting or any adjournments!or postponements thereof.$____________________________1)Created by Morningstar Document Research.0(http://documentresearch.morningstar.com/4;/#p^ a$=PF0*8X> @ l  !/  dMbP?_*+%,&٭e2?'٭e2?(٭e2?)٭e2?",D/??Beneficial OwnershipEquity UtilizationEquity Utilizat (1)Beneficial Owne (1)!STOCK OWNERSHIP OF CERTAIN BENESTOCK OWNERSHIP OF (1)Committees and MeetingsCommittees and (1)!Fees of Independent Registered !Compensation Discussion and Ana!How Executive Compensation is D Base SalaryAnnual Incentive PlanAnnual Incentive (1) IncentivesSummary CompensationStock Option GrantsOutstanding Equity Awards!2016 OPTION EXERCISES AND STOCK!Potential Payments Upon TerminaDirector Compensation2016 DIRECTOR COMPENSATION2016 DIRECTOR C (1)!Securities Authorized for Issua!AMENDED AND RESTATED 2014 OMNIB AMENDED AND RESTATED 2014 (1)! IF YOU HAVE NOT VOTED VIA THE IF YOU HAVE NOT VOTED (2)U } I"} $ } } $ } y } $ } U} $ } } $ } y } $ } } $ } } $ } y } $      NxStage Medical, Inc.PRE 14A 04/14/2017kc IF YOU HAVE NOT VOTED VIA THE INTERNET OR TELEPHONE, FOLD ALONG THE PERFORATION, DETACH AND RETUR     ! 1. Election of Directors:  For  Withhold      For  Withhold      For  Withhold              $  01 - Jeffrey H. Burbank  ?  ?    02 - Heyward R. Donigan  ?  ?    03 - Robert G. Funari  ?  ?              $  04 - Daniel A. Giannini  ?  ?    05 - Earl R. Lewis  ?  ?    06 - Jean K. Mixer  ?  ?       07 - Craig W. Moore ? ?08 - Reid S. Perper   ?   ? 09 - James J. Peters ? ?$____________________________1)Created by Morningstar Document Research.0(http://documentresearch.morningstar.com/.] ;/#%3I=PF0*8X> @ l  G  dMbP?_*+%,&٭e2?'٭e2?(٭e2?)٭e2?",D/??Beneficial OwnershipEquity UtilizationEquity Utilizat (1)Beneficial Owne (1)!STOCK OWNERSHIP OF CERTAIN BENESTOCK OWNERSHIP OF (1)Committees and MeetingsCommittees and (1)!Fees of Independent Registered !Compensation Discussion and Ana!How Executive Compensation is D Base SalaryAnnual Incentive PlanAnnual Incentive (1) IncentivesSummary CompensationStock Option GrantsOutstanding Equity Awards!2016 OPTION EXERCISES AND STOCK!Potential Payments Upon TerminaDirector Compensation2016 DIRECTOR COMPENSATION2016 DIRECTOR C (1)!Securities Authorized for Issua!AMENDED AND RESTATED 2014 OMNIB AMENDED AND RESTATED 2014 (1)! IF YOU HAVE NOT VOTED VIA THE IF YOU HAVE NOT VOTED (1)U } $} $ } 7} $ } } $ } I } $ } I } $ } $} $ } 8} $ } } $ } I } $ } I } $ } I      NxStage Medical, Inc.PRE 14A 04/14/2017kc IF YOU HAVE NOT VOTED VIA THE INTERNET OR TELEPHONE, FOLD ALONG THE PERFORATION, DETACH AND RETUR          For  Against  Abstain        1 Year  2 Years  3 Years  Abstain            ~   6 .Advisory vote on our named executive officers?  ?  ?  ?   ~  0 (Advisory vote on the frequency of future  ?  ?  ?  ?    compensation.           7 /advisory votes on our named executive officers?                compensation. ForAgainstAbstain      ForAgainstAbstain   ~ 2*To ratify the appointment of Ernst & Young ? ? ?   ~   5-To approve by-law amendment to adopt majority ? ? ?0(LLP as our independent registered public     0(voting standard for uncontested director1)accounting firm for the 2017 fiscal year.      elections. ForAgainstAbstain        ~ 4,To approve Amended and Restated 2014 Omnibus ? ? ?     1)Incentive Plan and its material terms for/'Internal Revenue Code ?162(m) purposes.$____________________________1)Created by Morningstar Document Research.0(http://documentresearch.morningstar.com/:4;/#3 S VyQ=PF0*8X> @2 Root Entry FBook  .H  !"#$%&'()*+,-./0123456789:;<=>?@ABCDEFGHIJKLMNOPQRSTUVWXYZ[\]^_`abcdefghijklmnopqrstuvwxyz{|}~      !"#$